We want you to know that there is hope and a way forward. Leiomyosarcomas are uncommon malignant tumors that grow from immature smooth muscle cells, accounting for up to 20 percent of all soft tissue sarcomas. They appear most often in large blood vessels and the pelvic area, including the uterus, and, to a lesser extent, in the extremities like the thighs. In its metastatic state, leiomyosarcoma most commonly spreads to the bloodstream, lung, and liver. Age is considered a high-risk factor for this disease. It can affect people of different ages.