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NLMSF
National Leiomyosarcoma Foundation
The ABC's of a New Diagnosis
May 22, 2023
Comprehensive overview of essential information for patients with a new LMS diagnosis, presented by the NLMSF.
Watch PodcastLeiomyosarcoma Education Videos
Video Topics
Educational videos on various LMS-related topics
The NLMSF provides educational videos on a wide range of topics relevant to LMS patients and their families. Click on a topic below to view available videos.
ABC's of a New DiagnosisBasic ResearchCaregivingChemotherapyCirculating Tumor DNAClinical TrialsCutaneous LeiomyosarcomaGeneral InformationImaging/RadiologyImmunotherapyMicrobiomeNutritionPathologyPEComaPatient Centered ResearchRadiation TherapySarculatorSurgical TreatmentSurvivorship CareUterine Fibroids
ABC's of a New Diagnosis
New Diagnosis Resources
Videos to help you understand a new LMS diagnosis
These videos provide essential information for patients who have recently been diagnosed with Leiomyosarcoma, covering the basics of the disease and what to expect.
YouTube Podcast
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NLMSF
National Leiomyosarcoma Foundation
Introduction to the ABC's of a New Diagnosis
January 16, 2022
Introductory session covering the essential information for newly diagnosed LMS patients.
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Mayo Clinic & NLMSF
Collaborative Presentation
The ABC's of a Sarcoma Diagnosis
2020
A collaborative presentation by the Mayo Clinic and NLMSF covering the fundamentals of a sarcoma diagnosis.
Watch PodcastBasic Research
Research Presentations
Scientific research on Leiomyosarcoma
These videos feature presentations from leading researchers in the field of Leiomyosarcoma, discussing the latest scientific discoveries and their implications for treatment.
YouTube Podcast
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Dr. Ryan Denu
MD Anderson Cancer Center, Houston, TX
Novel Leiomyosarcoma Subtypes Using Spatial Transcriptomics
2024
Dr. Denu discusses his research team's identification of two novel leiomyosarcoma subtypes - one with mesenchymal features and another enriched with smooth muscle cell markers - using spatial transcriptomics.
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Dr. Suzanne George
CMI LMS Project (Count Me In) / Broad Institute
LMS Project Updates: uLMS Pilot & NIH LMS SPORE Collaboration
2025
Updates to the LMS Project and next steps, including the uLMS pilot project and collaboration with the large NIH LMS SPORE program. Session covers community engagement, research aims, and how patient-partnered data can accelerate discoveries. NLMSF has co-funded support for the past 4 years.
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Dr. Priya Chudasama
Heibelberg University, Germany
The Importance of Telomeres in Leiomyosarcoma
July 19, 2022
Dr. Chudasama presents research on the role of telomeres in Leiomyosarcoma development and progression.
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Dr. Jonathan Trent
Sylvester Comprehensive Cancer Center, Miami University
LMS Connect Live
March 18, 2022
Program featuring Dr. Matthew Hemming (Dana-Farber) discussing laboratory models of leiomyosarcoma and Dr. Nicolas Llosa (Johns Hopkins) on the immune microenvironment of LMS.
Watch PodcastCaregiving
Caregiving Resources
Support for caregivers of LMS patients
These videos provide valuable information and support for caregivers of Leiomyosarcoma patients, addressing the unique challenges they face and offering practical guidance.
YouTube Podcast
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Dr. Marya Shegog
Lararex Foundation
Caregiving Counts
August 20, 2022
Dr. Marya Shegog discusses the important role of caregivers in supporting LMS patients and strategies for effective caregiving.
Watch PodcastChemotherapy and Targeted Agents
Treatment Options
Current chemotherapy and targeted treatments for LMS
These videos feature presentations from leading oncologists discussing current chemotherapy and targeted treatment options for Leiomyosarcoma patients.
YouTube Podcast
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Dr. Neeta Somaiah
MD Anderson Cancer Center, Houston, TX
Current Treatment Options for Leiomyosarcoma
June 20, 2024
Dr. Somaiah discusses the latest treatment options available for Leiomyosarcoma patients.
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Dr. Elise Nassif
MD Anderson Cancer Center, Houston, TX
How Patient Co-morbidities Impact Chemotherapy Treatment
April 14, 2023
Dr. Nassif explains how existing health conditions can affect chemotherapy treatment decisions and outcomes.
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Dr. Jonathan Trent
Sylvester Comprehensive Cancer Center, Miami, FL
The Use of Trabectedin in the Treatment of LMS
January 29, 2023
Dr. Trent discusses the application and effectiveness of Trabectedin (Yondelis) in treating Leiomyosarcoma.
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Dr. Neeta Somaiah
MD Anderson Cancer Center, Houston, TX
The Use of Votrient in the Treatment of Sarcomas
January 20, 2023
Dr. Somaiah explains how Votrient (pazopanib) is used in the treatment of Leiomyosarcoma and other sarcomas.
Watch PodcastCirculating Tumor DNA and Liquid Biopsies
Liquid Biopsy Research
Advancements in ctDNA testing for LMS
These videos discuss the emerging field of circulating tumor DNA (ctDNA) testing and liquid biopsies, which offer potential for less invasive monitoring of Leiomyosarcoma.
YouTube Podcast
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Expert Panel
Multiple Institutions
Circulating Tumor DNA Status and Future Directions for Sarcoma
2023
Panel discussion with experts including Dr. Nam Quoc Bui, Dr. Brian Compton, Dr. Elizabeth Davis, Dr. Erlinda Maria Gordon, Dr. Matthew Hemming, Dr. Elise Nasif, Dr. Joanna Pryzbyl, Dr. David Schulman and Dr. Jonathan Trent.
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Dr. Kristin Ganjoo & Dr. Katie Baker
Stanford University & Natera/Signatera
The Role of Circulating Tumor DNA (ctDNA) in Leiomyosarcoma
March 27, 2022
Dr. Ganjoo and Dr. Baker discuss how circulating tumor DNA testing can be used in the management of Leiomyosarcoma.
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Dr. Joanna Przybyl
The Research Institute of Montreal at McGill University
Circulating DNA in Uterine Leiomyosarcoma and Benign Uterine Leiomyosarcomas
February 24, 2022
Dr. Przybyl presents research on using circulating DNA to differentiate between uterine LMS and benign conditions.
Watch PodcastClinical Trials
Clinical Trial Information
Understanding and finding clinical trials for LMS
These videos provide information about clinical trials for Leiomyosarcoma, including how to find appropriate trials, what to expect, and how to determine if a trial is right for you.
YouTube Podcast
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Dr. Candace Haddox
Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA
Phase 1 Clinical Trial Using Peposertib and Liposomal Doxorubicin
February 26, 2025
Dr. Haddox discusses a novel Phase 1 clinical trial using Peposertib (M3814) and low-dose Liposomal Doxorubicin for metastatic Leiomyosarcoma and other soft tissue sarcomas.
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Dr. Seth Pollack
Lurie Cancer Center, Northwestern University, Chicago, IL
Phase II Clinical Trial Using Zanzalintinib (XL092)
January 31, 2025
Dr. Pollack discusses a Phase II clinical trial for Leiomyosarcoma patients using Zanzalintinib, a Tyrosine Kinase Inhibitor, currently enrolling at Northwestern University.
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Dr. John Mullinax
Moffitt Cancer Center, Tampa, FL
STRASS 2/3 Clinical Trial for Retroperitoneal Leiomyosarcoma
January 2025
Dr. Mullinax discusses the STRASS 2/3 clinical trial for the initial treatment of retroperitoneal Leiomyosarcoma and Liposarcoma.
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Dr. Vishu Avutu
Memorial Sloan Kettering Cancer Center, New York, NY
Phase 1a/2 Clinical Trial of GI-102 for Advanced Sarcoma
August 2024
Dr. Avutu discusses a Phase 1a/2 clinical trial of GI-102, which boosts the immune system by blocking CTLA-4 and increasing immune cells via IL-2, for advanced sarcoma patients.
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Expert Panel
Multiple Institutions
Clinical Trials Perspectives
February 2024
A panel discussion by sarcoma medical oncologists on clinical trials for Leiomyosarcoma and other sarcomas.
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Dr. Gregory Cote
Massachusetts General Hospital, Boston, MA
Lurbinectedin in Combination with Doxorubicin for Advanced Leiomyosarcoma
August 8, 2023
Dr. Cote provides an overview of clinical trials and discusses his trial using Lurbinectedin with Doxorubicin for advanced Leiomyosarcoma.
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Dr. Brian Van Tine
Siteman Cancer Center, Washington University, St. Louis, MO
Cabozantinib with PD-1 and CTLA-4 Inhibition and Other Trials
July 20, 2023
Dr. Van Tine discusses a Phase II trial of Cabozantinib with PD-1 and CTLA-4 inhibition and updates on three ongoing trials: Unesbulin, Pegylated Arginine Deiminase, and Olaparib with Temozolomide.
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Dr. Brian Van Tine
Siteman Cancer Center, Washington University, St. Louis, MO
Updates on Three Promising Active LMS Clinical Trials
April 14, 2023
Dr. Van Tine provides updates on three promising clinical trials for Leiomyosarcoma patients.
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Dr. Elise Nassif
MD Anderson Cancer Center, Houston, TX
The Efficacy of Early-Phase Clinical Trials in Soft Tissue Sarcoma
September 21, 2022
Dr. Nassif discusses the efficacy of early-phase clinical trials in soft tissue sarcomas, including Leiomyosarcoma.
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Dr. Brian Van Tine
Siteman Cancer Center, Washington University, St. Louis, MO
Unesbulin, New Treatment for Leiomyosarcoma
June 28, 2022
Dr. Van Tine discusses Unesbulin (PTC596) as a new treatment for Leiomyosarcoma in an upcoming clinical trial.
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Dr. Matthew Ingham
Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY
New Treatment Approaches for LMS in Preclinical or Clinical Trials
June 8, 2022
Dr. Ingham discusses new treatment approaches for Leiomyosarcoma in preclinical and clinical trials, including ATX-101 and Olaparib with Temozolomide.
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Dr. Gary Schwartz
Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY
Olaparib and Temozolomide for Advanced Uterine Leiomyosarcoma
August 24, 2022
Dr. Schwartz discusses a Phase II clinical trial evaluating Olaparib and Temozolomide for advanced uterine Leiomyosarcoma, moving to Phase III.
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Varun Monga, MD
Sarcoma Medical Oncologist — UCSF, San Francisco, CA
Clinical Trials Discussion
Hosted by the NLMSF. Dr. Monga discusses clinical trials relevant to Leiomyosarcoma patients.
Watch PodcastCutaneous Leiomyosarcoma
Cutaneous LMS Resources
Information on cutaneous Leiomyosarcoma
These videos provide information about cutaneous Leiomyosarcoma, a rare subtype of LMS that affects the skin, including diagnosis and treatment options.
No videos are currently available for this topic. Please check back later for updates.
General Information on Sarcoma Care – Multidisciplinary Approach
Sarcoma Care Resources
Comprehensive care approaches for sarcoma patients
These videos explore the multidisciplinary approach to sarcoma care, including systemic treatments, supportive care, and clinical trials, presented by experts in the field.
YouTube Podcast
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Dr. Elizabeth Davis
Vanderbilt Cancer Center, Nashville, TN
Patient Learning Hour: Sarcoma and Its Treatment
July 14, 2022
Dr. Elizabeth Davis presents a patient learning hour about sarcoma and its multidisciplinary treatment at Vanderbilt University.
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Dr. Elizabeth Davis
Vanderbilt Cancer Center, Nashville, TN
Treatment of Leiomyosarcoma
August 20, 2020
Dr. Davis discusses the treatment of Leiomyosarcoma, including systemic therapies, supportive care, and upcoming clinical trials.
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UCLA & NLMSF
Collaborative Presentation
UCLA-NLMSF Patient/Family LMS Education Symposium
February 2017
A symposium featuring presentations on drug development, personalized therapy, surgical management, radiation, immunotherapy, nutrition, and patient discussions for Leiomyosarcoma.
Watch PodcastImaging/Radiology
Imaging Resources
Role of imaging in LMS diagnosis and treatment
These videos discuss the role of imaging and radiology in the diagnosis, monitoring, and treatment planning for Leiomyosarcoma patients.
YouTube Recording
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Sarcoma Medical Oncologist
MD Anderson Cancer Center — Houston, TX
Targeting the Molecular and Immunological Features of LMS
June 9, 2023
Hosted by the NLMSF. Recording of a session covering imaging and immunologic considerations in LMS.
Watch VideoYouTube Recording
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Jonathan Trent, MD, PhD
Sylvester Comprehensive Cancer Center, Sarcoma Center — Miami, FL
Current Status and Future Directions of Immunotherapies in Soft Tissue Sarcomas
February 28, 2023
Hosted by the NLMSF. Overview of immunotherapies in soft tissue sarcomas and future directions.
YouTube Recording
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Christian Meyer, MD
Sarcoma Medical Oncologist — The Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD
Immunotherapy for Sarcoma: A Work in Progress
April 14, 2022
Hosted by the NLMSF. Dr. Meyer discusses insights from his Journal of Clinical Oncology article.
Immunotherapy
Immunotherapy Approaches
Emerging immunotherapy treatments for LMS
These videos explore the role of immunotherapy in treating Leiomyosarcoma, including current research, clinical applications, and future directions.
YouTube Podcast
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Dr. Christian Meyer
The Johns Hopkins Cancer Institute Sarcoma Center, Baltimore, MD
Immunotherapy in Sarcoma: Current Data and Promising Strategies
August 26, 2024
Dr. Meyer discusses the ASCO publication on immunotherapy in sarcoma, covering current data and promising strategies.
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Dr. Elise Nassif
MD Anderson Cancer Center, Houston, TX
Targeting the Molecular and Immunological Features of LMS
June 2024
Dr. Nassif discusses targeting molecular and immunological features of Leiomyosarcoma for immunotherapy.
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Dr. Jonathan Trent
Sylvester Comprehensive Cancer Center, Miami, FL
Current Status and Future Directions of Immunotherapy for soft tissue sarcomas
February 2016
Dr. Trent discusses the current status and future directions of immunotherapies for soft tissue sarcomas, including Leiomyosarcoma.
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Dr. Christian Meyer
The Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD
Immunotherapy for Sarcoma: A Work in Progress
April 14, 2022
Dr. Meyer discusses his recent article in the Journal of Clinical Oncology on the progress of immunotherapy for sarcoma.
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Dr. Sant Chawla
Sarcoma Oncology Center, Santa Monica, CA
Immunotherapy for Sarcoma
May 19, 2023
Dr. Chawla discusses the current state of immunotherapy for sarcoma patients and promising new approaches.
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Dr. Nicolas Llosa
Johns Hopkins University
Immune Microenvironment of LMS
March 18, 2022
Dr. Llosa presents research on the immune microenvironment of Leiomyosarcoma and implications for immunotherapy.
Watch PodcastThe Microbiome (Gut Health) and its Impact on Chemotherapy
Microbiome Research
Impact of gut health on LMS treatment
These videos explore the role of the microbiome (gut health) in influencing the effectiveness of chemotherapy treatments for Leiomyosarcoma patients.
YouTube Podcast
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Dr. Elise Nassif
MD Anderson Cancer Center, Houston, TX
The Microbiome (Gut Health) and its Impact on Chemotherapy Treatment
February 17, 2023
Dr. Nassif discusses how gut health influences the effectiveness of chemotherapy treatments for Leiomyosarcoma.
Watch PodcastNutrition
Nutrition Guidance
Dietary support for LMS patients
These videos provide guidance on nutrition for Leiomyosarcoma patients, including dietary recommendations during chemotherapy and clinical trials.
YouTube Podcast
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Alison Tierney, MS, RD, CD, CSO
Licensed Cancer Dietician and Cancer Survivor
Guidance on Diet During Chemo and Clinical Trials
May 22, 2024
Alison Tierney empowers cancer patients with dietary guidance to support their body before, during, and after treatment.
Watch PodcastYouTube Recording
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Josephine Dermawan, MD
Research Pathologist — Cleveland Clinic, Cleveland, OH
Pathology Perspectives and Recent Research
May 2024
Hosted by the NLMSF. Dr. Dermawan discusses pathology perspectives and her recent research publication.
Watch VideoYouTube Recording
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Alexander Lazar, MD
Sarcoma Pathologist — MD Anderson Cancer Center, Houston, TX
Basic Lecture on Pathology of Sarcoma
August 3, 2020
Hosted by the NLMSF. Foundational concepts in sarcoma pathology with relevance for treatment and research.
Watch VideoPathology
Pathology Insights
Understanding sarcoma pathology
These videos provide insights into the pathology of Leiomyosarcoma and other sarcomas, discussing diagnostic techniques and recent research.
YouTube Podcast
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Dr. Josephine Dermawan
Cleveland Clinic, Cleveland, OH
Perspectives on Pathology and Recent Research
May 2024
Dr. Dermawan discusses her perspectives on pathology and her recent research publication on sarcoma.
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Dr. Alexander Lazar
MD Anderson Cancer Center, Houston, TX
Basic Lecture on Pathology of Sarcoma
August 3, 2020
Dr. Lazar provides a basic lecture on the pathology of sarcoma, including Leiomyosarcoma.
Watch PodcastPEComa
PEComa Research
Updates on PEComa treatment and research
These videos discuss research updates and treatment options for PEComa, a rare type of sarcoma related to Leiomyosarcoma.
YouTube Podcast
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Dr. Andrew Wagner & Dr. Marco Schito
Dana-Farber Cancer Institute, Boston, MA & University of Arizona
PEComa Research Updates and Drug Repurposing
March 2024
Dr. Wagner provides PEComa research updates, and Dr. Schito discusses repurposing drugs for PEComa treatment through a patient-driven initiative.
Watch PodcastHow to Participate in Patient Centered Research
Patient Research Opportunities
Engaging in patient-driven research initiatives
These videos explain how patients can participate in patient-centered research initiatives like Count-Me-In and Pattern.org to advance Leiomyosarcoma research.
YouTube Podcast
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Ben Zola
Director, Count Me In LMS Project
Count Me In LMS Project and How to Participate
Unknown
Ben Zola discusses the Count Me In LMS Project and how patients can participate in this patient-driven research initiative.
Watch PodcastRadiation Therapy
Radiation Therapy Options
Radiation treatments for LMS
These videos discuss the role of radiation therapy in the treatment of Leiomyosarcoma, including its applications and effectiveness.
YouTube Podcast
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Dr. B. Ashleigh Guadagnolo
MD Anderson Cancer Center, Houston, TX
Hypofractionated Radiation for Extremity and Truncal Sarcomas
February 2025
Dr. Guadagnolo discusses whether hypofractionated radiation should be adopted as the standard of care for extremity and truncal sarcomas.
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Dr. Anusha Kalbasi
UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA
The Role of Radiation in the Treatment of Sarcoma
September 17, 2020
Dr. Kalbasi discusses the role of radiation therapy in the treatment of sarcoma, including Leiomyosarcoma.
Watch PodcastSarculator
Sarculator Tool
Prognostic tool for sarcoma patients
These videos explain the Sarculator, a prognostic tool used to predict outcomes for sarcoma patients, including those with Leiomyosarcoma.
YouTube Podcast
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Dr. Kenneth Cardona
Emory University Winship Cancer Institute, Atlanta, GA
The Role of Nomograms in the Treatment of LMS and the Potential Future Impact of Circulating Tumor DNA
February 17, 2022
Dr. Cardona discusses the role of nomograms, including the Sarculator, in the treatment of Leiomyosarcoma.
Watch PodcastSurgical Treatment
Surgical Options
Surgical approaches for LMS
These videos discuss surgical treatment options for Leiomyosarcoma, including techniques and considerations for optimal outcomes.
YouTube Podcast
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Dr. Kenneth Cardona
Emory University Winship Cancer Institute, Atlanta, GA
Surgery for Leiomyosarcoma
September 24, 2020
Dr. Cardona discusses surgical approaches for Leiomyosarcoma, including considerations for retroperitoneal and other sites.
Watch PodcastVideo Recording
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Eric Toloza, MD
Thoracic Surgeon, Moffitt Cancer Center — Tampa, FL
Current Thoracic Surgical Procedures for Sarcoma Lung Metastases
April 12, 2024
Presented by Dr. Toloza. Hosted by the NLMSF.
Watch VideoVideo Recording
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William Tseng, MD
Sarcoma Surgical Oncologist — City of Hope National Medical Center
Retroperitoneal Leiomyosarcoma — Consensus Guidelines and Daily Practice
August 22, 2022
Hosted by the NLMSF. Presented by Dr. Tseng.
Watch VideoVideo Recording
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Aime Crago, MD
Sarcoma Surgical Oncologist — Memorial Sloan Kettering Cancer Center, New York, NY
Surgical Management of LMS
November 2, 2020
Hosted by the NLMSF. Dr. Crago discusses surgical management principles for Leiomyosarcoma.
Watch VideoVideo Recording
JF
Jeffery Farma, MD
Sarcoma Surgeon — Fox Chase Medical Center, Philadelphia, PA
Perspectives on Surgical Management of LMS/Sarcoma
April 2, 2020
Hosted by the NLMSF. Dr. Farma shares perspectives on surgical management of LMS and sarcomas.
Watch VideoSurvivorship Care Planning
Survivorship Resources
Support for LMS survivors
These videos provide guidance on survivorship care planning for Leiomyosarcoma patients, focusing on long-term health and quality of life.
Video Recording
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Shelley Fuld Nasso, MPP
CEO — National Coalition for Cancer Survivorship (NCCS)
Survivorship Care Planning
October 4, 2022
Hosted by the NLMSF.
Watch VideoUterine Fibroids – What You Should Know Before Having Fibroid Surgery, Leiomyomas vs. Leiomyosarcoma
Uterine Fibroids Information
Differentiating fibroids and LMS
These videos provide information on uterine fibroids, their differences from Leiomyosarcoma, and important considerations before undergoing fibroid surgery.
YouTube Podcast
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Dr. Joanna Przybyl
The Research Institute of Montreal at McGill University
Circulating DNA in Uterine Leiomyosarcoma and Benign Uterine Leiomyomas
February 24, 2022
Dr. Przybyl presents research on using circulating DNA to differentiate between uterine Leiomyosarcoma and benign uterine leiomyomas (fibroids).
Watch PodcastVideo Recording
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Panel of Experts
Hosted by the NLMSF
Uterine Fibroids – What You Should Know Before Having Surgery
A panel of experts discusses key considerations before fibroid surgery, including differentiating leiomyomas and leiomyosarcoma.
Introductory brief about the medical panel presentation Watch VideoVideo Recording
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O. Sandra Madueke-Laveaux, MD
Associate Professor of OB-GYN — University of Chicago
Differentiating Leiomyosarcoma from Benign Leiomyoma: Toward a Blood Biomarker
October 27, 2023
Hosted by the NLMSF. Dr. Laveaux discusses the clinical challenge of distinguishing LMS from benign leiomyoma and her work on a pre-operative blood biomarker.
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