Local Therapies for Metastatic Sarcoma
Why, When, and How?
Framework for integrating local therapies into metastatic sarcoma care.
Local therapies (surgery, radiation, ablation, embolization) can provide durable control and symptom relief in selected patients with oligometastatic or limited-progression disease, often in conjunction with systemic therapy.
- Patient selection and timing are critical; multidisciplinary review is essential.
- Goals include prolonging progression-free survival, palliation, or enabling systemic therapy breaks.
Lung Metastases Treatment
Overview and Outcomes
Strategies include surgery, SBRT, and ablative techniques.
Liver Metastases Treatment
Embolization
Catheter-directed therapy to restrict tumor blood supply.
May be considered for unresectable lesions, symptom control, or progression confined to the liver.
Ablation Therapies
Thermal or chemical destruction of tumor tissue.
Options include radiofrequency, microwave, or cryoablation, often for limited number/size lesions.
Spinal Metastatic Disease
Treatment Progress and Quality of Life
Modern approaches to control pain, maintain function, and stabilize spine.