July 15National LMS Awareness Day
A global initiative uniting researchers, clinicians, and advocates to accelerate precision research and improve patient outcomes in LMS.
A global initiative bringing together the Sarcoma Research Community for a collaborative focus on the future of Leiomyosarcoma investigational research and clinical trials with a mission of:
Consensus papers from the International LMS Research Roundtable and its patient-advocacy partners.
This publication brings together an international group of leiomyosarcoma specialists, researchers, and patient advocates to provide a current consensus on how leiomyosarcoma should be diagnosed, treated, and studied, and to identify the questions researchers still need to answer.
This white paper arose from a leiomyosarcoma research meeting in October 2020 hosted by the National Leiomyosarcoma Foundation (NLMSF) and Sarcoma Patients EuroNet (SPAEN). It summarizes state-of-the-art treatments, identifies knowledge gaps and unmet needs, and guides the community toward clinical trials and basic research that can close those gaps.
NATIONAL LEIOMYOSARCOMA FOUNDATION
2026-2027 RESEARCH GRANT ANNOUNCEMENT
LOI deadline: April 15th, 2025
Please submit to:
The National Leiomyosarcoma Foundation (NLMSF) is dedicated to meeting the needs of leiomyosarcoma (LMS) patients, caregivers, and families through education and research. In order to facilitate advances in the treatment of LMS through research, the NLMSF is accepting research proposals for pilot studies that will launch "out of the box" ideas and new research trajectories to move the field forward.
All direct funds must be used to support LMS research. Proposals involving any scientific discipline are allowed including those related to biomarkers and imaging. This award was created to support basic and translational research. Other highly translational projects that are not based in a traditional wet lab may be considered (for example: in silico computational biology, radiomics, etc.); however, investigators who are considering submitting a non-traditional research project are highly encouraged to discuss the appropriateness of their project ahead of time. Clinical research (interventional trials) will not be supported by this award; however, work studying human samples and annotated data sets obtained from clinical trials is allowed. Studies requiring human samples must show documentation of IRB approval prior to awarding of funds (or document waivers if applicable).
The NLMSF seeks LOIs for research grant funding. The total award will be $50,000 per year for 2 years. Indirect costs should not exceed 10% of the total budget.
The LOI should consist of:
Mission and Purpose of The International LMS Research Roundtable
The National Leiomyosarcoma Foundation (NLMSF) is dedicated to meeting the needs of LMS patients, caregivers, and families through education and research. Proposals for pilot studies launching innovative research trajectories are now being accepted.
Find all the 2024 RFP details here: View the 2024 LMS research grant RFP details
Division Chief, Perinatal Pathology, Brigham and Women's Hospital
Professor of Pathology, Harvard Medical School
Project: Build a platform for characterization of uterine leiomyosarcoma using advanced AI techniques by combining genetic and histology markers to predict recurrence.
Professor, Gynecologic Oncology, Univ. Hospitals Leuven, Belgium
Projects include investigating PI3K/mTOR inhibition effects on LMS tumors and combining humanized PDX models with immune checkpoint blockade.
McGill University, Montreal, Quebec, Canada
Project: Development of a Multi-Omic Liquid Biopsy Assay for the Pre-Operative Diagnosis of Uterine Leiomyosarcoma.
German Cancer Research Center, Heidelberg, Germany
Project: Spatial Heterogeneity and Therapeutic Implications of Activated Telomere Maintenance Mechanisms in LMS.
Dr. Seth Pollack's Grant Presentation at CTOS: Watch Video
Download LMS Cell & PDX Workgroup Request
LMS INTERNATIONAL RESEARCH ROUNDTABLE WORKGROUP No. 1: PDX/CELL LINE Models for LMS
